Open shaders folder then delete the opengl folder if it is there.
Emulation->Configure... then click on Graphics on the left
Click on the Advanced tab and turn onAccurate Multiplication
The Disk Shader Cache currently has a bug when Accurate Multiplication is turned off causing it to load all shaders slowly from zero every time you start the game and makes the precompiled cache extrememly large + the RAM usage skyrockets until you crash.
Please create a seperate support topic post about your issue then. Fill out the template it gives you and provide a log file to go with it. That way we can see if there are any problems we can identify.