Failed to complete framework shutdown - Unable to start application: Os { code: 2, kind: NotFound, message: "The system cannot find the file specified." }

THIS IS JUST "LOG"strong text
[ 0.191629] Input input_common\gcadapter\gc_adapter.cpp:Adapter:21: GC Adapter Initialization started
[ 0.285022] Input input_common\udp\client.cpp:Client:164: Udp Initialization started
[ 0.285037] Input input_common\udp\client.cpp:StartCommunication:309: Starting communication with UDP input server on 127.0.0.1:26760
[ 0.356169] Frontend yuzu\main.cpp:GMainWindow:232: yuzu Version: yuzu 777
[ 0.356176] Frontend yuzu\main.cpp:GMainWindow:247: Host CPU: Intel(R) Core™ i5-4590 CPU @ 3.30GHz | AVX2 | FMA
[ 0.356234] Frontend yuzu\main.cpp:GMainWindow:249: Host OS: Windows 10 Version 2009
[ 0.356253] Frontend yuzu\main.cpp:GMainWindow:251: Host RAM: 15.89 GB
[ 0.356254] Frontend yuzu\main.cpp:GMainWindow:253: Host Swap: 34.18 GB
[ 0.716882] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.4.0) applied successfully
[ 0.724623] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.4.0) applied successfully
[ 0.735613] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.2.0) applied successfully
[ 0.739335] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.2.0) applied successfully
[ 0.747561] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.15.0) applied successfully
[ 0.751534] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.15.0) applied successfully

THIS IS “OLD” LOG TXT
[ 0.261182] Input input_common\gcadapter\gc_adapter.cpp:Adapter:21: GC Adapter Initialization started
[ 0.369375] Input input_common\udp\client.cpp:Client:164: Udp Initialization started
[ 0.369612] Input input_common\udp\client.cpp:StartCommunication:309: Starting communication with UDP input server on 127.0.0.1:26760
[ 0.466452] Frontend yuzu\main.cpp:GMainWindow:232: yuzu Version: yuzu 777
[ 0.466459] Frontend yuzu\main.cpp:GMainWindow:247: Host CPU: Intel(R) Core™ i5-4590 CPU @ 3.30GHz | AVX2 | FMA
[ 0.466527] Frontend yuzu\main.cpp:GMainWindow:249: Host OS: Windows 10 Version 2009
[ 0.466545] Frontend yuzu\main.cpp:GMainWindow:251: Host RAM: 15.89 GB
[ 0.466547] Frontend yuzu\main.cpp:GMainWindow:253: Host Swap: 34.18 GB
[ 0.884559] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.4.0) applied successfully
[ 0.892154] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.4.0) applied successfully
[ 1.241640] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.2.0) applied successfully
[ 1.245485] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.2.0) applied successfully
[ 1.302644] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.15.0) applied successfully
[ 1.306764] Loader core\file_sys\patch_manager.cpp:PatchRomFS:437: RomFS: Update (v0.15.0) applied successfully

In order for us to provide better support, we need to see the log generated by Citra. This guide will walk you through how you can obtain the log file: How to Upload the Log File.

FAQ - yuzu please read this FAQ to learn how to fix said issue. It’s usually antivirus or you requiring to reinstall yuzu by deleting %localappdata%\yuzu\ and running their yuzu installer again to pull latest.